Published in: "Embryonic and Fetal Antigens in Cancer", Volume 2, Proc. Second Conf. 1972: (Anderson NG, Coggin JH Jr, Cole E, and Holleman JW, Eds.), pp. 1-375, Natl. Tech. Information Service, U. S. Dept. Commerce, Springfield, Virginia.

Edited by N.G. Anderson, J.H. Coggin, Jr., Elaine Cole and J.W. Holleman

Sponsored by the Molecular Anatomy Program,
Oak Ridge National Laboratory, Oak Ridge TN, 37830

Supported by: The U.S. Atomic Energy Commission and the National Cancer Institute.

Session I. Differentiation, Retrogenesis, and Cancer

Session Chairman: N.G. Anderson

"Opening Remarks",
J.L. Liverman

"Mated Models of Gene Regulation in Eukaryotes",
Paul R. Herstein and John H. Frenster

"The Placenta as a Model for Aging and for Aging-Linked Neoplastic Diseases",
Robert H. Burstein, Sam Frankel, Samuel D. Soule, and Herman T. Blumenthal

"Immunoreproduction: Selected Studies on the Antigens of the Female Reproductive System",
Linda L. Fox and C. Alex Shivers

"Hormone Control of Differentiation and Embryonic Antigens in Human Placental Tumor Cells",
R. A. Pattillo, M.T. Story, J. M. Hershman, E. Delfs, and R. F. Mattingly

"Some Data to Support the Theory that Ceramidelactoside is the Antigen in All types of Cancer Cells Which Stimulates an Autoimmune Response".
Chloe Tal

"Variant Hemoglobins in Aged Animals",
R. A. Popp

Session Chairman: R. B. Herberman

"Chemical Structures and Immunological Reactivities of Some Membrane-Bound Glycosphingolipids of Normal, Fetal, and Transformed Cells",
Sen-Itiroh Hakomori, Bader Siddiqui, and Shigeko Kijimoto

"The Role of the Mammary Cell Membranes Containing a Unique Glycoprotein in the Regression of Spontaneous Tumors"
George Miroff

"Phase-Specific Autoantigens (Fetal) in Model Tumor Systems",
J. H. Coggin, Jr., and N.G. Anderson

"Detection of Cell Surface Chages in Human Leukemic Leukocytes Using Plant Lectins",
Stephen Krauss, and Madonna A. Black

"Antibodies to Fetal Antigen",
Chou-Chik Ting, David H. Lavrin, and R. B. Herberman

"Phase-Specific Antigens",
James W. Holleman and Winifred G. Palmer

"Quantitative Immunofluorescence Measurements of Some Epstein-Barr Antigen-Antibody Reactions",
W. W. Harris and B.W. Harrell

"Glycoproteins Excreted by SV40-Transformed Cells",
J. W. Eveleigh

Session III: Roundtable Discussion
Session Chairman: A. J. Girardi

"Application of Immunoperoxidase Bridge Technique in Studies of Tumor Tissues with Antibody to Tumor-Associated Antigen (TAA)",
Konrad C. Hsu, Earl A. Zimmerman, Leonard Rudin, Paul LoGerfo, Sidney Bennett, and Myron Tannenbaum

"Session III. Roundtable Discussion:

Session IV: Model Systems for Studying Immune Reactivity to Fetal Antigens in-vivo and in-vitro".

Session Chairman: J.H. Coggin, Jr.

"Studies on the Embryo-Fetal Origin of the Individual Tumor-Associated Antigens of Chemically Induced Tumors",
G. Parmiani and R. Lembo

"The Relationship of Hamster Fetal Antigen to SV40 Tumor-Specific Transplantation Antigen",
Anthony J. Girardi and Phyllis Reppucci

"Resurgence of Fetal Gene Products in Transplanted Rat Tumors",
Francoise Farron and W. Eugene Knox

"Presence of Fetal Antigens In Human Malignant Neoplasms as Demonstrated by Immunofluorescence Microscopy",
R. Mesa-Tejada, J. A. Fierer, J. V. Klavins, M. Weiss, and J. I. Berkman

"Similar Responses of Mice and Rats to Fetal and Leukemic Tissues",
R. L. Tyndall, J. A. Otten, and P. C. Estes

"Modification of the Spleen-Colony-Forming Assay to Demonstrate Immunologic Cross-Reactivity of Antigens Common to Tumor and Fetal Cells",
F. A. Salinas, Jane A. Smith, and M.G. Hanna, Jr.

"Fetal Antigen Expression on Chemically Induced Rat Neoplasms",
R. W. Baldwin, Dorothy Glaves, and B. M. Vose

"Immunochemical Studies of Extramedullary Hematopoiesis and of the Participation of Leukocytes in Carcinogenesis",
D. Dufour, S. Lemieux, A. Tremblay, and R. Estrada

"Simultaneous Presence of Tumor-Specific and Fetal Antigens on Guinea Pig Tumor Cells",
Tibor Borsos and Edward J. Leonard

Session V. Carcinoembryonic Antigens

Session Chairman: N. Zamcheck

"Summary of Current Status (March 1972) of Clinical Studies of Carcinoembryonic Antigens (CEA)",
N. Zamcheck, T. L. Moore, P. Dhar, and H. Z. Kupchik

"Carcinoembryonic Antigen in Patients with Carcinoma of the Digestive Tract",
E. D. Holyoke, G. Reynoso, and T. Chu

"A Preliminary Survey by Double-Antibody Radioimmunoassay of CEA Levels in the Plasm From Patients with Various Disorders and in the Urine of Patients with Bladder Tumors",
D. J. R. Laurence

"Tumor-Specific Antigen (CEA) in Tumor Extracts and Urine from Cancer Patients",
Karel Kithier, Muhyi Al-Sarraf, anf Jan Cejka

"Immunochemical Studies with the Carcinoembryonic Antigen",
Arnold E. Reif, Cynthia M. Robinson, Faramarz Naeim, and Luis M. de la Maza

"Chemical Characteristics of CEA and Its Presence in Bronchiogenic Carcinoma, Rhabdomyosarcoma, and Regional Enteritis Tissue",
B.J. Haverback, and B.J. Dyce

"Tumor Antigen (CEA) in Gastric Adenocarcinoma Masked by a Binding Substance, Likely an Antibody",
B. J. Dyce and B.J. Haverbeck

"Evaluation of Fluorescence Polarization for Carcinoembryonic Antigen (CEA) Detection",
K. C. Tsou, Mary G. McCoy, and K. W. Lo

"Evaluation of a Radioimmunoassay Method for Carcinoembryonic Antigen Using Zirconyl Phosphate. II. Carcinoembryonic Antigen in Normal Plasma",
Gustavo Reynoso, T. M. Chu, Hans J. Hansen, and Gerald P. Murphy

"Comparison of Radioimmunoassays for Carcinoembryonic Antigens",
Herbert Z. Kupchik, Jans J. Hansen, Jeffrey J. Sorokin, and Norman Zamcheck

"The Triple-Isotope Double-Antibody Assay: Application to the Carcinoembryonic Antigen",
Marianne L. Egan, John E. Coligan, Joel T. Lautenschleger, and Charles W. Todd

Session Chairman: N. G. Anderson

"Cyclic AMP and the Differentiation of Mouse Neuroblastoma Cells in Culture",
Kedar N. Prasad

"Activation of Gamma Glutamyl Transpeptidase - An Early Neoplastic Change in Rat Liver Induced by Chemical Carcinogens",
Silvio Fiala and Emerich S. Fiala

"Bromodeoxyuridine-Induced Suppression of SV40 T Antigen",
John W. Kreider, Bert Del Villano, William H. Shoff, and Eugene A. Davidson

"Alpha Fetoprotein (Alpha FP) in Human Tumors",
Muhyi Al-Sarraf, Karel Kithier, V.K. Vaitkevicius, and M.D. Poulik

"Serum Alpha Fetoprotein in American Patients",
Edgar W. Hall and K. Robert McIntire

"Synthesis and Sequential Appearance of Alpha Fetoproteins in Carcinogenic-Fed Rats",
Edward J. Sarcione

Session Chairman: R. Lange

"Induction of Neoplasms in Nonhuman Primates by Chemical Carcinogens - Correaltion of Serum Alpha Fetoprotein and Appearance of Liver Tumors",
Richard A. Adamson, Clara F. Smith, and Dan W. Dalgard

"Quantitative Studies of Alpha Fetoprotein During Progression of Hepatocellular Carcinoma",
K. R. McIntire and C. L. Vogel

"Properties and Occurrence of Alpha Fetoprotein in Serum of Healthy Adults and Patients with Hepatitis and Cancer of the Liver",
Erkki Ruoslahti and Markku Seppala

"Fetuin and Bovine Fetoprotein: A Comparison",
Karel Kithier, Muhyi Al-Sarraf, and M. D. Poulik

"Retrogenesis: Problems and Prospects",
N. G. Anderson and J. H. Coggin, Jr.

Attendees:

Additional References:

1. "Mated Models of Gene Regulation in Eukaryotes".

2. Symposium "Cancer and Chemistry", Fourth Conf. on Embryonic and Fetal Antigens in Cancer, Charleston, SC, (Anderson NG and Coggin JH, eds).

3. "Selective Control of DNA Helix Openings during Gene Regulation".

4. "Oncogenes as Molecular Targets within Active Chromatin".