Published in: Biochimica et Biophysica Acta, vol. 106, no. 3: pp. 577-591 (December 2, 1965): 

"Composition and Metabolism of Lipids within Repressed and Active Chromatin of Interphase Lymphocytes".

Herbert G. Rose and John H. Frenster
Bronx V.A. Hospital and the Rockefeller Institute
New York, NY


Summary:

A recently developed method for the isolation of chromatin, either repressed or active in ribonucleic acid synthesis, has been applied to nuclei of interphase calf thymus lymphocytes. During the course of chromatin isolation, the nuclear membranes were removed, as observed by electron microscopy. The lipids of these chromatin fractions were isolated and identified and their metabolism studied by measuring incorporation of [1,3-14C2]glycerol. These studies reveal that active chromatin is much richer in phospholipids than is repressed chromatin. In addition, the lipids of active chromatin have a much more active metabolism. Confirmation of these results was obtained by electron-microscopic autoradiography following incorporation of [3H]-glycerol into the lipids of isolated nuclei. 



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euchromatin: "the most active portion of the genome within the cell nucleus".