Published in Nature, vol. 261, no. 5560 pp. 519-521 (June 10, 1976).

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                        Goldstein L.
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                        Role for small nuclear RNAs in "programming" chromosomal information?
                        Nature. 1976 Jun 10;261(5560):519-21. No abstract available.
                        PMID: 934289 [PubMed - indexed for MEDLINE]


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                        Goldstein L.
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                        Role for small nuclear RNAs in "programming" chromosomal information?
                        Nature. 1976 Jun 10;261(5560):519-21. No abstract available.
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                     2:
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                         Nuclear RNA transcripts from Drosophila melanogaster ribosomal RNA genes
                         containing introns.
                         Nucleic Acids Res. 1980 Jan 11;8(1):67-84.
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                     88:
                         Lobo SM, Marzluff WF.
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                         Synthesis of U1 RNA in isolated mouse cell nuclei: initiation and 3'-end
                         formation.
                         Mol Cell Biol. 1987 Dec;7(12):4290-6.
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                     89:
                         Prestayko AW, Busch H.
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                         Low molecular weight RNA of the chromatin fraction from Novikoff hepatoma
                         and rat liver nuclei.
                         Biochim Biophys Acta. 1968 Dec 17;169(2):327-37. No abstract available.
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                         Functions of the GTPase Ran in RNA export from the nucleus.
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                         Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm.
                         Nature. 1992 Feb 20;355(6362):730-2.
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                         The role of the cap structure in RNA processing and nuclear export.
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                         Howe JG, Steitz JA.
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                         Localization of Epstein-Barr virus-encoded small RNAs by in situ hybridization.
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                         Organization, transcription, and regulation in the animal genome.
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                         Lukowiak AA, Narayanan A, Li ZH, Terns RM, Terns MP.
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                         The snoRNA domain of vertebrate telomerase RNA functions to localize the
                         RNA within the nucleus.
                         RNA. 2001 Dec;7(12):1833-44.
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                         TBP dynamics in living human cells: constitutive association of TBP with mitotic
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                         Nuclear and cytoplasmic adenovirus RNA. Differences between 5'-terminal of
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                          A comparison of nuclear and cytoplasmic viral RNAs synthesized early in
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                          Nuclear retention elements of U3 small nucleolar RNA.
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                          Small RNA molecules related to the Alu family of repetitive DNA sequences.
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                          Transcription during mammalian spermatogenesis with special reference to
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                          Isolation and partial characterization of dinoflagellate U1-U6 small RNAs
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                          SnRNAs, SnRNPs, and RNA processing.
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Additional References:

Reviews:

1. Frenster JH, "Ultrastructural Probes of Active DNA Sites, and the RNA Activators of DNA".

2. Frenster JH, "Mechanisms of Repression and De-Repression within Interphase Chromatin", In-Vitro, vol. 1, pp. 78-101 (1965).

3. Frenster JH, and Herstein PR, "Gene De-Repression", New Eng. J. Med. 288: 1224-1229 (June 7, 1973).

4. Frenster JH, "Ultrastructure and Function of Heterochromatin and Euchromatin", in:  "The Cell Nucleus", vol. 1, pp. 565-580, (1974), (Busch H, ed.), New York, Academic Press.

5. Frenster JH, Nakatsu SL, and Masek MA, "Ultrastructural Probes of DNA Templates within Human Bone Marrow and Lymph Node Cells", "Advances in Cell and Molecular Biology", vol. 3, pp. 1-19 (1974), ed. DuPraw EJ, New York: Academic Press.

6. Frenster JH, "Selective Control of DNA Helix Openings during Gene Regulation", Cancer Research, vol. 36, pp. 3394-3398 (September, 1976).

7. Frenster JH, "Selective Gene De-Repression by De-Repressor RNA", in "Eukaryotic Gene Regulation", Volume 1, pp. 131-143, 1980, edit. Kolodny GM, CRC Press, Boca Raton, FL, USA.

8. Frenster JH, "Activation of DNA Transcription within Repressed Chromatin", 14th John Innes Symp., 2001.

9. Hovsepian JA, and Frenster JH, "RNA-Induced Melting of DNA during Selective Gene Transcription", Molec. Biol. Cell, vol. 13, supp. p. 239a (November, 2002).

10. Hovsepian JA, and Frenster JH, "Euchromatin as an Extensile Force within Mammalian Cell Nuclei", Molec. Biol. Cell, vol. 14, supp. p. 93a (November, 2003).



 

References:

1. Frenster JH, Allfrey VG, and Mirsky  AE, "Metabolism and Morphology of Ribonucleoprotein Particles from the Cell Nucleus of Lymphocytes" Proc. Natl. Acad. Sci. USA, vol. 46, pp. 432-444 (April, 1960).

2. Frenster JH, Allfrey VG, and Mirsky AE, "In-Vitro Incorporation of Amino Acids into the Proteins of Isolated Nuclear Ribosomes", Biochim. Biophys. Acta 47: 130-47 (1961).

3. Frenster JH, Allfrey VG, and Mirsky, AE, "Repressed and Active Chromatin Isolated from Interphase Lymphocytes", Proc. Natl. Acad. Sci., USA, vol. 50, no. 6, pp. 1026-1032 (Dec. 1963):

4. Frenster JH, "Ultrastructural Continuity between Active and Repressed Chromatin", Nature, vol. 205, no. 4978, pp. 1341-1342 (March 27, 1965).

5. Frenster JH, "Nuclear Polyanions as De-Repressors of Synthesis of Ribonucleic Acid", Nature, vol. 206, no. 4985, pp. 680-683 (May 15, 1965).

6. Frenster JH, "A Model of Specific De-repression within Interphase Chromatin", Nature, vol. 206, no. 4990, pp. 1269-1270 (June 19, 1965 ).

7. Frenster JH, "Localized Strand Separations within Deoxyribonucleic Acid during Selective Transcription", Nature, vol. 208: no. 5013, pp. 894-896 (November 27, 1965).

8a. Frenster JH, "Correlation of the Binding to DNA Loops or to DNA Helices with the Effect on RNA Synthesis", Nature, vol. 208, no. 5015, p. 1093 (December 11, 1965).

8b. Czihak G, "Evidence for Inductive Properties of the Micromere-RNA in Sea-urchin Embryos",
Naturwissenschaften, vol. 52, no. 6, pp. 141-142 (1965).

9. Frenster JH, "Electron Microscopic Localization of Acridine Orange Binding to DNA within Human Leukemic Bone Marrow Cells", Cancer Research, Vol. 31, 1128-1133 (August, 1971).

10. Frenster JH, "Ultrastructural Probes of Chromatin within Living Human Lymphocytes", Nature (New Biology) Vol. 236, No. 67, pp. 175-176, (April 12, 1972).

11. Nakatsu SL, Masek MA, Landrum S, and Frenster JH, "Activity of DNA Templates During Cell Division and Cell Differentiation", Nature, vol. 248, No. 5446, pp. 334-335 (March 22, 1974).

12a. Goldstein L, "Stable Nuclear RNA Returns to Post-Division Nuclei Following Release to the Cytoplasm During Mitosis", Exp. Cell Research, vol. 89, no. 2, pp. 421-425 (December, 1974).

12b. Goldstein L, "Role for Small Nuclear RNAs in Programming Chromosomal Information?", Nature 261: 519-521 (1976).

12c. Goldstein L, Wise GE, and Ko C, "Small Nuclear RNA Localization during Mitosis: An Electron Microscope Study", J Cell Biol, vol. 73, no.2, pp. 322-31 (May, 1977).

13. Dobrzelewski J, Milewska Z and Panusz H, "Effect on Transcription of Low-Molecular-Weight RNA from Calf Thymus Chromatin", Acta Biochim. Pol. vol. 27, no. 2, pp. 75-87 (February, 1980).

14. Frenster JH, "Single-Cell Analysis of DNase I-Sensitive Sites during Neoplastic and Normal Cell Differentiation within Human Bone Marrow", Ann. N.Y. Acad. Sci. 567: 334-336 (Aug. 4, 1989).

15a. Frenster JH, "Nuclear RNA Species Activate DNA Transcription Within Chromatin", FASEB Journal, Vol. 13, No. 7, A1506 (April 23, 1999).

15b. Frenster JH, "Oncogenes as Molecular Targets within Active Chromatin", Clinical Cancer Research, vol. 5, suppl. l, p. 3855s, (624), (November, 1999).

16. Frenster JH, "Nuclear Ribosomes and RNA-RNA Duplexes", Mol. Biol. Cell vol. 11, suppl. p. 20a (December, 2000).

17. Frenster JH, "Activation of DNA Transcription within Repressed Chromatin by Nuclear RNA Species", RNA 2001, p. 237 (The RNA Society, Bethesda, Maryland, 2001).

18. Frenster JH, "Yeast  RNA  Re-Programming  of  Already-Active  Mammalian Chromatin", RNA 2002, p. 592, (2002, Bethesda, MD: The RNA Society).

19. Frenster JH, "Uni-Polar Clustering of Lymphocyte DNA Templates Toward Neoplastic Target Cells Within Hodgkin’s Disease Lymph Nodes", Proc. Am. Assoc. Cancer Res. vol. 43, p. 1134 (March, 2002).

20. Frenster JH, and Hovsepian JA, "RNA Feedback Mechanisms during Eukaryotic Gene Regulation", Biomolecular Systems Initiative, "Northwest Symposium on Systems Biology", p. 15, Oct. 17-18, 2002.

21. Hovsepian JA, and Frenster JH, "RNA-Induced Melting of DNA during Selective DNA Transcription", Molec. Biol. Cell, vol. 13, supp. p. 239a (November, 2002).

22. Frenster JH, and Hovsepian JA, "Overshoot in Late Telophase for RNA Re-Programming of Mitotic Chromatin", "RNA2003", p. 211 (2003), The RNA Society, Bethesda, MD, USA.

23. Hovsepian JA, and Frenster JH, "Euchromatin as an Extensile Force within Mammalian Cell Nuclei", Molec. Biol. Cell, vol. 14, supp. p. 93a (November, 2003).


Additional Links:

Links to Euchromatin Activator RNA Reviews:
Links to Euchromatin Activator RNA Research:
Links to RNA as a Therapeutic Agent:
Links to Hodgkin Lymphoma Immuno-Pathology:
Links to Activated T-Lymphocyte Immunotherapy:
Links to Medical Systems Biology:



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euchromatin: "the most active portion of the genome within the cell nucleus".